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Paclitaxel

Paclitaxel

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Paclitaxel is a mitotic inhibitor used in cancer chemotherapy; it and docetaxel represent the taxane family of drugs. Paclitaxel was discovered in 1967 as a result of a U.S. National Cancer Institute-funded screening program; Monroe Wall and Mansukh Waniisolated the drug from the bark of the Pacific yew, Taxus brevifolia, and named it "taxol". Developed commercially by Bristol-Myers Squibb (BMS), the generic name has changed to "paclitaxel" with BMS selling the compound under trademark as TaxolTaxol is formulated with a polyethoxylated castor oil (BASF Kolliphor EL) and ethanol; paclitaxel is also available as a injectable suspension ofalbumin-bound drug. Clinicians sometimes use the abbreviation "PTX" for paclitaxel, which is discouraged because it is not a unique identifier.